Angelo is the brother of Sophia Petrillo and uncle of Dorothy Zbornak, Gloria Petrillo and Phillip "Phil" Petrillo.

Strangely enough in his first appearance,he appeared to be a priest from Sicily.In reality he never joined the priesthood because he had an attraction towards a beautiful woman and eventually married her,although no children were mentioned as a result of this relationship. Eventually he moved to Miami after losing his business, although what business it was never mentioned.He moved into the apartment of Stan's late Uncle Morris whom Stan and Dorothy inherited the apartment building from,which allowed Dorothy to allow her uncle Angelo to live in the apartment for free.

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