Regina was a fictional character featured on the popular 1980s sitcom The Golden Girls. She is the sister of Eleanor Grisanti, thus making her Sophia Petrillo's maternal aunt and Dorothy Zbornak's great-aunt. She once told Sophia that she swam nude with Charles Boyer. Sophia thinks of her as quite a low person, saying that she's always two steps away from the gutter. Angelo Sr. implies that she is stinky.

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